Stanford University President Marc Tessier-Lavigne announced on Wednesday, July 19, that he will be stepping down after a panel of experts found significant flaws in various studies that he had supervised more than a decade ago. While the panel cleared him of personally committing scientific fraud, Tessier-Lavigne was criticized for allowing work to be published that contained errors and "manipulation of research data."

In a letter to the community, Tessier-Lavigne indicated that ongoing discussions about the panel's report would hamper his leadership of the university, at least in the near term, and that the university would be better off with his resignation as of Aug. 31.

Tessier-Lavigne, a neuroscientist who was appointed Stanford president in 2016, has been under increased scrutiny in recent months after various stories reported by the campus newspaper, The Stanford Daily, alleged in November that numerous papers that were published under his supervision had falsified data and other flaws. The Daily had asked several science misconduct investigators to review Tessier-Lavigne's papers.

The series of stories prompted Stanford to appoint an independent scientific panel last December to review his work. The panel, led by former federal judge Mark Filip, released its report on Wednesday morning.

The panel collected more than 50,000 documents in its review of 12 papers that involved Tessier-Lavigne, including five in which he was the principal author. The review stopped short of accusing Tessier-Lavigne of personally falsifying data in the five studies that he led. It also concluded that he did not know about the manipulation of research data that occurred in his lab and was not reckless in failing to identify such manipulation prior to publication.

"Nonetheless, based on the available research record and other factors, each of the papers has serious flaws in the presentation of research data; in at least four of the five papers, there was apparent manipulation of research data by others," the review concluded.

The panel, which included five scientists who were assisted by three technical consultants, found that a group of three papers published between 1999 and 2001 -- one in Cell and the other two in Science -- re-used a single blot image and represented it as a product of three different experiments.

A fourth paper, which was published in Nature in 2004, contained images that "indicate manipulation of research data." A fifth paper, published in Nature in 2009, included "multiple errors in the work underlying the paper and the presentation of research data and methodology that, at a minimum, fall below customary standards of scientific rigor and process."

The panel also found that the 2009 paper in Nature, which was published while Tessier-Lavigne was working for Genentech, had multiple problems and that the process through which its science was developed in Tessier-Lavigne's lab "lacked the rigor expected for a paper of such potential consequence." The panel found that it had contained "various errors and shortcomings."

"In that regard, the Panel has identified issues in the paper’s underlying calculation of data and presentation of scientific images, along with inadequate disclosures regarding various aspects of the paper’s experimental methodologies," the report states.

However, the Scientific Panel disputed a finding reported by the Daily that the 2009 paper in Nature was investigated by Genentech, which had uncovered fraud; the biotech company publicly stated it did not make that finding. The panel also stopped short of concluding that Tessier-Lavigne personally manipulated the data.

The panel "did not find evidence to conclude that Dr. Tessier-Lavigne engaged in, directed, or knew of the misconduct when it occurred, and the misconduct was of such a nature that a scientist exercising reasonable care could not have been expected to have detected it at the time."

That said, the panel confirmed that several of the 12 papers it had reviewed "exhibit manipulation of research data." The panel also found that Tessier-Lavigne had "failed to decisively and forthrightly correct mistakes in the scientific record."

In a cover letter accompanying the report, Filip noted that Tessier-Lavigne will retract at least three of the five papers in which he was the lead author and, "at minimum, pursue robust corrections as to the other two."

"The Scientific Panel agrees that significant action is appropriate to correct the scientific record," Filip wrote.

In his letter to the community, Tessier-Lavigne asserted that he had "never submitted a scientific paper without firmly believing that the data were correct and accurately presented" and said he was "gratified that the Panel concluded I did not engage in any fraud or falsification of scientific data."

He also acknowledged the panel's conclusions about areas where he "should have done better."

"I agree that in some instances I should have been more diligent when seeking corrections, and I regret that I was not," Tessier-Lavigne wrote. "The Panel's review also identified instances of manipulation of research data by others in my lab. Although I was unaware of these issues, I want to be clear that I take responsibility for the work of my lab members.

"I expect there may be ongoing discussion about the report and its conclusions, at least in the near term, which could lead to debate about my ability to lead the University into the new academic year."

Tessier-Lavigne confirmed in his letter that he will retract three papers and correct two others.

These findings have also caused him to "further reassess the processes and controls I have in place."

"While I continually maintain a critical eye on all the science in my lab, I have also always operated my lab on trust – trust in my students and postdocs, and trust that the data they were presenting to me was real and accurate," Tessier-Lavigne wrote. "Going forward, I will be further tightening controls, including, for example, more systematically matching processed images to original raw data, both in the course of each scientific study and especially when bringing a study to publication.

"I will vigorously apply this and other best practices to ensure that these kinds of problems do not recur."

With the resignation, the University's Board of Trustees is preparing to begin its search for Tessier-Lavigne's replacement. Jerry Yang, president of the university's Board of Trustees, said the Board has appointed Richard Saller, a European studies professor, to serve as president of Stanford University on an interim basis. His appointment will begin on Sept. 1 and will continue until the next president of the university is in place.

Saller, who was the dean of the School of Humanities and Sciences after joining Stanford in 2007, is the Kleinheinz Family Professor of European Studies. Before coming to Stanford he served as the provost and dean of social sciences at the University of Chicago, where he spent 22 years, according to an article about him in Stanford Magazine.

His history with Stanford dates back to when he was a fellow at Stanford's Center for Advanced Study in the Behavioral Sciences in 1986-1987. In 2001, he was part of a team of specialists in ancient history who reviewed the academic standing of Stanford's classics department.

Saller is a Roman historian with interests in social, economic and cultural history. He received bachelor's degrees in Greek and history from the University of Illinois and a doctorate from Cambridge University, according to his Stanford bio. He was inducted into the American Academy of Arts and Sciences as a fellow in 2005.

He has taught at Swarthmore College and held visiting professorships and fellowships at the University of California at Berkeley and Jesus College, Cambridge.

Yang outlined the plans for hiring Tessier-Lavigne's successor in a statement: "In the coming weeks, the Board will appoint a search committee and will share more information about the process for selecting the University's next president."

Yang lauded Tessier-Lavigne for his seven years of service and "outstanding accomplishments" which included the creation of Stanford's first new school in seventy years, the Doerr School of Sustainability, and his work in ensuring that "Stanford retained its standing as a world-class institution through the unique challenges presented by the COVID-19 pandemic."

But in light of the report, Yang said that the board has decided to accept Tessier-Levigne's resignation and "agrees with him that it is in the University’s best interests." Yang noted that Tessier-Lavigne will continue in his position as a tenured professor in the Department of Biology.